Published Patents & Applications

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In inverse chronological order of first publication date :

  1. Libert, C., Vandenbroucke, R., Steeland, S.
    Means and methods to treat inflammation.
    Priority date 2016.10.18
    WO/2018/073216A1 (2018.04.26)
  2. Elewaut D., Raes J., Vereecke L., Joossens M., Tito-Tadeo RY.
    Means and methods to treat inflammation-associated disorders or conditions.
    Priority date 2016.06.23
    WO/2017/220802 (2017.12.28)
  3. Elewaut D., Venken K., Tavernier J., Zabeau L., Favreau M., Menu E.
    Anti-cancer therapy using a leptin antagonist and an iNKT-cell activator.
    Priority date 2016.06.01
    WO/2017/20704 (2017.12.07)
  4. Verstraete K., Peelman F., Braun H., Beyaert R., Savvides S.
    Novel TSLP inhibitors.
    Priority date 2016.04.05
    WO/2017/174556 (2017.10.12)
  5. Raes J., Elewaut D., Tito-Tadeo Y.R, Joosens M.
    Microbial marker in inflammatory arthritis diseases.
    Priority date 2015.12.22
    WO/2017/109059 (2017.06.29)
  6. Zajonc, D., Van Calenbergh S., Elewaut D., Guillaume J.
    Sphingamide Compounds and Methods for Binding iNKT Cells.
    Priority date 2015.11.13
    WO/2017/083830 (2017.05.18)
  7. Saelens, X, Schepens, B, Rossey I, Graham B, McLellan J, Gilman M.
    Immunologlobulin single variable domain antibody against rsv prefusion f protein.
    Priority date 2015.06.18
    WO/2016/203052 (2016.06.20)
  8. Callewaert, N, De Visscher, C.
    Improved production of lipase in yeast
    Priority date 2014.02.12
    WO2016/087496 (09.06.2016)
  9. Vandenabeele, P, Vanden Berghe, T., Augustyns, K., Joossens, J., Van Der Veken, P., Hofmans, S.
    3,4-diaminobenzensulfonamide derivatives for inhibiting cell death
    Priority date 2014.11.14
    WO2016/075330 (19.05.2016)
  10. Elewaut, D, Lambrecht, S.
    A method of treating joint disease
    Priority date 2014.09.30
    WO2016/050796 (27.04.2016)
  11. Dondelinger, Y, Vandenabeele, P, Bertrand, M, Declercq, W.
    Necroptosis inducing MLKL fragment and inhibitors thereof.
    Priority date 2014.03.20
    WO2015/140313 (24.09.2015)
  12. Vandenabeele, P, Cauwels, A, Vanden Berghe, T.
    Targeting of Interleukin-1 and -18 signaling in treatment of septic shock.
    Priority date 2014.01.21
    WO2015/110346 (30.07.2015)
    WO:
  13. Vandendriessche, T., Chuah, M., De Bleser, P.
    Muscle-specific nucleic acid regulatory elements and methods and use thereof.
    Priority date 2014.01.21
    WO2015/110499 (30.07.2015)
    WO:
  14. Callewaert, N., Santens, F.
    Cells producing Fc containing molecules having altered glycosylation patterns and methods and use thereof.
    Priority date 2013.09.05
    WO2015/032899 (12.03.2015)
    WO:
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  15. Kufer, P., Raum, T., Munz, M., Pendzialek, J., Fiers, W., Saelens, X. & Roose, K.
    Antibody constructs for Influenza M2 and CD3.
    Priority date 2013.03.15.
    WO2014/140368 (18.09.2014)
    WO:
    EU:
  16. Beyaert, R, Braun, H, Lambrecht, BN, Hammad, H.
    Novel interleukin-33 inhibitors.
    Priority date 2012.12.10.
    WO2014/090800 (19.06.2014)
    WO:
    EU:
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  17. Saelens, X, Cardoso, M, Depicker, A, Muyldermans, S.
    Anti-influenza antibody.
    Priority date 2012.12.11.
    WO2014/090865 (19.06.2014)
    WO:
    EU:
  18. Maelfait, J, Beyaert, R, van Loo, G.
    A20 inhibitors for the treatment of respiratory viral infections.
    Priority date 2011.06.23
    WO 2012/175735 (27.12.2012)
    WO:
  19. Steyaert, J., Callewaert, N., Laeremans, T., Pardon, E., Vandewalle, K. & Claes, K.
    Tools and methods for expression of membrane proteins.
    Priority date 2012.01.19
    WO 2013/107905 (25.07.2013)
    WO:
  20. Saelens, X., Schepens, B. & Fiers, W.
    Respiratory syncytial virus vaccine.
    Priority date  2010.11.15
    WO 2012/065997 (24.05.2012) - US2013/0315916 (28.11.2013)
    WO:
    US:  
  21. Libert, C, De Jonckheere, E, Vandenbroucke, R.
    MMP8 inactivating antigen binding proteins.
    Priority date  2010.11.04
    WO2012/059513 (10.05.2012) - US20140037646 (06.02.2014) - EP2635606B1 (31.12.2014)
    WO:
    EU: 
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  22. Berx, G & Raspé, E.
    23. ZEB metagene expression signature for prognosis of breast cancer patients.
    Priority date  2010.10.29
    WO2012/056047 (03.05.2012) - US2013/0324438 (05.12.2013)
    WO:
    US:  
  23. Remon, J P, De Geest, B, De Koker, S, Grooten, J, Vervaet C.
    Porous degradable polyelectrolyte microspheres as vaccine vector.
    Priority date 2010.10.24
    WO2012/025551 (01.03.2012)
    WO:
  24. Piens, K, Vervecken, W.
    De-Mannosylation of Phosphorylated  N-Glycans.
    Priority date 2010.09.29
    WO2012042387A2 (05.04.2012)
    WO:
  25. Callewaert, N, Guerfal, M.
    Increased protein expression through increased membrane formation.
    Priority date 2010.06.17.
    WO2011/157761A1 (22.12.2011) - Eur. Patent EP2582811 (24.04.2013) - US2013/0137140 (30.05.2013) - Austr. Patent AU2011267036B2 (14.05.2015)
    WO:
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  26. Chuah, M, Vanden Driessche, T, De Bleser, P.
    Cardiac-specific nucleic acid regulatory elements and methods and use thereof.
    Priority date 2009.10.29.
    WO2011/051450 (05.05.2011) - Austr. Patent AU 2010311376 (12.06.2014) - US Patent US9353164  (31.05.2016)
    WO:
  27. Callewaert, N, Wiersma, D.
    Methods for producing substantially homogenous hybrid of complex N-glycans in methylotrophic yeasts.
    Priority date 2009.10.16.
    US2012/0029174 (02.02.2012) - US2011/0092374 (21.04.2011)
    US : 
  28. Callewaert, N, Vervecken, W, Tiels, P, Remaut, H.
    Hydrolysis of mannose-1-phospho-6-mannose linkage to phospho-6-mannose.
    Priority date 2009.09.29.
    WO2011/039634 (07.04.2011) - US2013/0158239 (20.06.2013) - SG 201202311-5 (23.06.2015)
    WO:
    US :
  29. Callewaert, N, Batni, A, Festjens, N, Huygen, C.
    Mycobacterium mutants for vaccines with improved protective efficacy.
    Priority date 2009.07.28.
    WO2011/012662 (03.02.2011) - US Patent 8,685,415 (01.04.2014) - Eur. Patent EP2459204B1 (31.12.2014) - Chinese Patent CN 201080043070 (11.03.2015)
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  30. Callewaert, N, De Schutter, K, Tiels, P, Lin, Y-C.
    Genome sequence (nucleic acids) of Pichia Pastoris and use thereof for recombinant production of proteins
    Priority date 2009.05.22
    WO2010/135678 (25.11.2010) - US Patent 8,440,456 (14.05.2013)
    WO:
    US : 
  31. Baird, M.S., Al Dulayymi, J.R., Grooten, J., Vander Beken, S. & Maza-Inglesias, M.
    Methods and compositions.
    Priority date 2009.01.29.
    WO/2010/086667 (05.08.2010)
  32. Bouche, M-PLA, Vanlandschoot, P, Sablon, E, Depla, E, De Buck, S, Saelens, X, Schepens, B.
    Pulmonary administration of immunoglobulin single variable domains and constructs thereof.
    Priority date 2009.01.14.
    WO2010/081856 (22.07.2010)
    WO:
  33. Callewaert, N., De Pourcq, K., Geysens, S. &  Meuris, L.
    Cells producing glycoproteins having altered glycosylation patterns and methods and use thereof.
    Priority date 2008.08.08
    WO2010/015722 (11.02.2010) - Eur. Patent EP2331701 (20.03.2013) - Austr. Patent AU2009279062 (16.01.2014) - US Patent 8,815,580 (26.08.2014)
    WO:
    EU : 
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  34. Chen, C. & Libert, C.
    Blood serum marker for detection and diagnosis of Alzheimer's disease.
    Priority  date 2008.06.11,
    WO2009/150172 (17.12.2009) - Eur. Patent 2304442 (14.11.2012) - US2011/0100816 (05.05.2011)
    WO:
    EU : 
    US : 
  35. Hultberg, A, Maassen, B, Vanlandschoot, P, Depla, E, Stortelers, C, Verrips, CT, Van Gucht, S, Melero, J, Saunders, MJS, De Haard, JJW, Weiss, RA, Temperton, NJ, Saelens, X, Schepens, B, Szyroki, A.
    Amino acid sequences directed against envelope proteins of a virus and polypeptides comprising the same for the treatment of viral diseases.
    Priority date 2008.06.05.
    WO2009/147248 (10.12.2009) - US 2011/0182897 (28.07.2011)
    WO:
    US : 
  36. De Veylder, L., Quimbaya, M., Takahashi, N., Raspé, E. & Berx, G.
    Minichromosome maintenance complex interacting protein involved in cancer.
    Priority  date 2008.05.29
    WO2009/144311 (03.12.2009) - US2011/0229491 (22.09.2011)
    WO:
    US : 
  37. Vanlandschoot, P, Verrips, CT, Hultberg, A, Maassen, B, Beyaert, R.
    Amino acid sequences directed against Toll-like receptors and their use for the treatment of diseases related to Toll-like receptors.
    Priority date 2008.05.15.
    WO2009/138494 (19.11.2009)
    WO:
  38. Baird, MS, Al Dulayymi, JR, Theunissen, C, Koza, G, Vander Beken, S, Grooten, J.
    Compounds for use in therapy
    Priority date 2008.04.22
    WO2009/130506 (29.10.2009) - US Patent 8,889,894 (11.11.2014)
    WO:
    US : 
  39. Baird, MS, Al Dulayymi, JR, Theunissen, C, Koza, G, Vander Beken, S, Grooten, J.
    Adjuvants for use in vaccination.
    Priority date 2008.04.22
    WO2009/130508 (29.10.2009) - US Patent 8,728,515 (20.05.2014)
    WO:
    US : 
  40. Chuah, M, Vanden Driessche, T, De Bleser, P.
    Liver-specific nucleic acid regulatory elements and methods and use thereof.
    Priority  date 2008.04.21.
    WO2009/130208 (29.10.2009) - US2011/0184049 (28.07.2011)
    WO:
    US : 
  41. Berx, G., Vandewalle, C. & Raspé, E.
    Use of SIP1 as determinant of breast cancer stemness.
    Priority date 2008.02.26
    WO2009/106578 (03.09.2009) - US2011/0104183 (05.05.2011)
    WO:
    US : 
  42. Beyaert, R., Marynen, P., Baens, T. & Heyninck, K.
    Inhibitors of MALT1 proteolytic activity and uses thereof.
    Priority date 2007.11.21
    WO2009/065897 (28.05.2009) - Eur. Patent 2222326 (18.04.2012) - US Patent 8,309,523 (13.11.2012) - Can. Patent CA 2,705,694 (24.02.2015)
    WO:
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  43. Chen, C. & Contreras, R.
    Diagnostic test for the detection of early stage liver cancer.
    Priority date 2007.06.14
    WO2008/152070 (18.12.2008) - US Patent 8,003,392 (23.08.2011)
    WO:
    US  :
  44. Callewaert, N., Vervecken, W., DePourcq, K., Geysens, S. & Guerfal, M.
    Yarrowia lipolytica and Pichia pastoris HAC1 nucleic acids (Glycosylation of molecules).
    Priority date 2007.04.03
    WO2008/120107 (09.10.2008) -  - US Patent 8,026,083 (27.09.2011) - Can. Patent CA 2,682,578 (26.05.2015)
    WO:
    US  :
  45. Brouckaert, P., Elewaut, D. & Huyghe, L.
    Combination therapy using tumour necrosis factor and an alfa-galactosyl ceramide.
    Priority date 2007.02.21
    WO2008/101951 (28.08.2008) - US Patent 7,959,907 (14.06.2011) - Eur Patent 2117583 (22.05.2013)
    WO:
    US : 
    EP : 
  46. Declercq, W, Denecker, G, Vandenabeele, P.
    Sunscreen compositions
    (Pharmaceutical and sunscreen compositions comprising caspase-14).
    Priority date 2006.09.01.
    WO2008/025830 (06.03.2008)
    WO:
  47. Rottiers, P.
    Microbial intestinal delivery of obesity related peptides.
    Priority date 2006.05.03
    WO2007/128757 (15.11.2007) - US 2009/0074737 (19.03.2009)
    WO:
    US:  
  48. Ward, M, Vervecken, W, Contreras, R.
    Filamentous fungi having reduced udp-galactofuranose content.
    Priority date 2006.04.05
    WO2007/123801 (01.11.2007) - US2011/0104750 (05.05.2011)
    WO:
    US : 
  49. Contreras, R, De Vusser, K, Revell, I.
    Novel vaccine against Trypanosoma cruzi infection.
    Priority date 2006.03.17.
    WO2007/107488 (27.09.2007) - Mex. Patent MX 297207 (12.03.2012) - US 2011/0038887 (17.02.2011) - US Patent US 12/225,396 (12.05.2015)
    WO:
    US :
  50. Rottiers, P. & Snoeck, V.
    Induction of mucosal tolerance to antigens.
    Priority date 2005.11.29
    WO2007/063075 (07.06.2007) - US 2009/0148389 (11.06.2009)
    WO:
    US : 
  51. Rottiers, P., Vandenbroucke, K. & Iserentant, D.
    Use of recombinant yeast strain producing an anti-inflammatory compound (in the manufacture of a medicament) to treat colitis.
    Priority date 2005.10.03
    WO2007/039586 (12.04.2007) - US 2008/0254014 (16.10.2008)
    WO:
    US : 
  52. Rottiers, P. & Vandenbroucke, K.
    Anti-Tnf alpha producing lactic acid bacteria for the treatment of chronic enterocolitis (Novel treatment of chronic enterocolitis).
    Priority date2005.08.30
    WO2007/025977 (08.03.2007) - US 2008/0274084 06.11.2008)
    WO:
    US : 
  53. Beyaert, R, Revets, H, Huang, L.
    Treatment of EGFR dependent tumours by ABIN (A20-binding inhibitor of NF kappaB)    .
    Priority date 2005.04.14
    WO2006/108844 (19.10.2006) - US Patent US7893026 (22.02.2011)
    WO:
    US :
  54. Chen, C, Contreras, R.
    Aging biomarker.
    Priority date 2004.12.01
    WO2006/058878 (08.06.2006) - US Patent 7,993,822 (09.08.2011) - Eur. Patent EP1825259 (18.11.2009) - US 2008/0003180 (03.01.2008)
    WO:
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  55. Beyaert, R, El Bakkouri, K.
    ABIN-mediated protection against lung inflammatory disease.
    Priority date 2004.09.13
    WO2006/029981 (23.03.2006)
    WO:
  56. Remaut, E, Iserentant, D.
    Method to improve Lactococcus preservation.
    Priority date 2004.08.20.
    WO2006/018446 (23.02.2006) - US 2007/0258965 (08.11.2007)
    WO:
    US : 
  57. Vandenabeele, P, Lamkanfi, M, Denecker, G.
    A novel human CARD-only protein that inhibits pro-IL-1beta maturation.
    Priority date 2004.05.27.
    WO2005/118632 (15.12.2005) - US2008/0108546 (08.05.2008)
    WO:
    US :
  58. Steidler, L, Neirynck, S.
    Self-containing Lactobacillus strain.
    Priority date 2004.05.18.
    WO2005/111194 (24.11.2005) -  US 2008/0253990 (16.10.2008)
    WO:
    US : 
  59. Fiers, W, Birkett, A.
    Influenza immunogen and vaccine.
    Priority date 2003.12.10.
    WO05/055957 (23.06.2005) - US Patent 7,361,352 (22.04.2008) - Austr. Patent 2004296886 (12.10.2008)
    WO:
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  60. Contreras, R., Callewaert, N., Vervecken, W. & Kaigodorov, V.
    Modification of protein glycosylation in methyloptrophic yeast.
    Priority date 2003.11.14
    WO2005/049807 (02.06.2005) - US Patent 7,507,573 (24.03.2009) - Austr. Patent AU2004291886 (30.04.2009)
    WO:
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  61. Lamkanfi, M, Kalai, M, Vandenabeele, P.
    Caspase derived CARDs.
    Priority date 2003.12.08.
    WO2005/025591 (24.03.2005)
  62. Beyaert, R, Carpentier, I.
    Ubiquinated TNF Receptor 2 and its uses.
    Priority date 2003.07.01.
    WO2005/003167 (13.01.2005) - US2006/0134737 (22.06.2006)
    WO:
    US :
  63. Grooten, J, Heirman, I.
    Use of cytosolic phospholipid hydroperoxide glutathione peroxidase to reduce tumor growth.
    Priority date 2003.06.25.
    WO2005/000341 (06.01.2005)
  64. Mertens, N, Kelly, A.
    Use of caspase enzymes for maturation of engineered recombinant polypeptide fusions.
    Priority date 2003.02.21.
    WO2004/074488 (02.09.2004) - Eur. Patent EP1597369 (03.10.2007)  - Austalian Patent 2004213586 (15.01.2009)
    WO:  
    EU :   
    AU : 
  65. Contreras, R, Geysens, S.
    Improved protein secretion in eukaryotic cells.
    Priority date 2003.03.12.
    WO2004/081201 (23.09.2004) - U.S. Patent 7,491,510 (17.02.2009)
    WO:  
    US :
  66. Beyaert, R, Schotte, P.
    The use of YOPs as caspase inhibitor.
    Priority date 2003.01.20.
    WO2004/064713 (05.08.2004) - US 2006/0019882 (26.01.2006)
    WO:
    US : 
  67. Callewaert, N, Contreras, R.
    A serum marker for measuring liver fibrosis.
    Priority date 2003.01.14.
    WO2004/063753 (29.07.2004) - US Patent 7,244,619 (17.07.2007) - Chinese Patent CN ZL200480006752.3 (15.10.2014) - Eur. Patent EP 04701959.1 (22.04.2015) - US 12/225,396 (12.05.2015)
    WO:
    EU:
    US :
  68. Steidler, L, Neirynck, S.
    Mutant proteins showing increased secretion    .
    Priority date 2002.12.19.
    WO2004/056850 (08.07.2004)
    WO:
  69. Steidler, L, Rottiers, P, Remaut, E.
    Self-containing Lactobacillus strain.
    Priority date 2002.11.15.
    WO2004/046346 (03.06.2004) - US 2005/0276788 (15.12.2005)
    WO:
    US : 
  70. Reeves, J, Khorana, G, Callewaert, N, Contreras, R.
    High level protein expression system.
    Priority date 2003.05.20.
    US2004/0029229 (12.02.2004).
    US : 
  71. Contreras, R, Callewaert, N, Geysens, S, Kaigodorov, V, Vervecken, W.
    Protein glycosylation modification in Pichia Pastoris     (with inhibition of the expression of the OCH1 protein).
    Priority date 2003.06.25.
    WO2004/003194 (08.01.2004) - US Patent 8,883,445 (11.11.2014) - Eur. Patent EP1294910 (24.05.2013) - Austr. Patent 2003238051 (13.03.2008)
    WO:
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    EP : 
    AU : 
  72. Steidler, L.
    Methods and means to promote gut absorption.
    Priority date 2002.06.19.
    WO04/001020 (31.12.2003) - US Patent 7,601,799 (13.10.2009) - Eur. Patent EP 1513545 (19.03.2008) - Austr. Patent AU2003250250 (14.02.2008)
    WO: 
    US : 
    EU : 
    AU : 
  73. Callewaert, N, Contreras, R.
    A marker for measuring liver cirrhosis.
    Priority date 2002.04.16.
    WO03/087833 (23.10.2003) - US Patent 7,355,512 (26.02.2008) - Eur. Patent 1495328 (18.06.2014) - Can. Patent 2482686 (03.04.2012)
    WO:
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    EU:
    Can:
  74. Van Roy, F, Berx, G, Strumane, K.
    Method to control tumor progression and invasiveness (Method of modulating e-cadherin mediated cell adhesion).
    Priority date 2002.02.22.
    WO03/070759 (28.08.2003) - Eur. Patent 1482965 (08.04.2009) - US Patent 7569668 (04.08.2009)
    WO:
    EU :
    US :
  75. Libert, C, Wielockx, B, Van Molle, W, Mahieu,T.
    Novel pharmaceutical compositions for tumour treatment.
    Priority date 2002.01.24.
    WO03/061684 (31.07.2003)
  76. Beyaert, R, Janssens, S.
    A novel splice variant of MyD88 and uses thereof    .
    Priority date 2002.01.10.
    WO03/057728 (17.07.2003) - US Patent US7122656 (17.10.2006) - Austr. Patent AU2003205615 (25.9.2008)
    WO:
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    AU :
  77. Contreras, R, Chen, C.
    Method to isolate genes involved in aging.
    Priority date 2001.11.29.
    WO03/045988 (05.06.2003) - US2005/0191639 (01.09.2005)
    WO:
    US :
  78.  Sehra, S, Grooten, J.
    Method to obtain protection against bystander allergen.
    Priority date 2001.11.13.
    WO03/041731 (22.05.2003) - US 2005/0019321 (27.01.2005)
    WO:
    US : 
  79. Daemen, M, Heemskerk, V, van 't Veer, C, Denecker, G, Wolfs, T, Vandenabeele, P, Buurman, W, Parkkinnen, J.
    Methods and active substances for protecting organs.
    Priority date 2001.09.18.
    US2003053998 (20.03.2003) & US20050277106 (15.12.2005).
      &  
  80. Beyaert, R, Wielockx, B, Van Huffel, S, Delaei, F, Libert, C.
    ABIN mediated hepatitis protection.
    Priority date 2001.06.22.
    WO03/000280 (03.01.2003) - US Patent 7094756 (22.08.2006) - Eur. Patent EP1397154 (02.08.2006) - Austr. Patent AU2002350412 (15.06.2006)
    WO:
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    EP :
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  81. Hochepied, T, Libert, C, Van Molle, W, Wielockx, B.
    Usage of zinc for preventing TNF-induced pathology during cancer therapy.
    Priority date 2001.05.08.
    WO02/089919 (14.11.2002)
    WO:
  82. Steidler, L.
    Self-containing Lactococcus strain.
    Priority date 2001.05.03.
    WO02/090551 (14.11.2002) - US Patent 7,780,961 (24.08.2010) - Eur. Patent EP1383897 (28.06.2006) - Austr. Patent 2002314040 (28.06.2007)
    WO:
    US : 
    EU : 
    AU : 
  83. De Filette, M, Deroo, T, Fiers, W, Maras, M, Min Jou, W.
    Recombinant oligomeric protein complexes with enhanced immunogenic potential.
    Priority date 2001.01.18.
    WO02/074795 (26.09.2002) - US Patent 7,449,188 (11.11.2008) - Eur. Patent 1362109 (10.06.2009) - Can. Patent CA 2,435,000 (25.03.2014)
    WO:
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    AU:

  84. Contreras, R, Eberhardt, I, Luyten, W, Reekmans, R.
    Bax-responsive genes for drug target identification in yeast and fungi.
     Priority date 2000.12.22.
    WO02/064766 (22.08.2002) - US Patent 7,101,990 (05.09.2006)
    WO:
    US : 

  85. Ameloot, P, Brouckaert, P, Fiers, W.
    Methods and means for the deoligomerisation of oligomeric molecules.
    Priority date 2000.10.26.
    WO02/34780 (02.05.2002)
    WO:

  86. Van Roy, F, Speleman, F, Van Roy, N, Staes, K, Vandepoele, K.
    Identification of neuroblastoma tumor suppressor genes.
    Priority date 2000.09.27.
    WO02/26815 (04.04.2002) - US 2004/0132030 (08.07.2004)
    WO:
    US : 

  87. Van Roy, F, Goossens, S, Janssens, B, Vanpoucke, G.
    Novel alpha-catenin expressed in heart and testis  (Antibody and uses relating to alpha-T Catenin).
    Priority date 2000.12.17.
    WO02/04636 (17.01.2002) - Eur. Patent EP1299536 (27.03.2013) -US Patent 7,341,866 (11.03.2008)
    WO:

    EU :

    US :

  88. Mertens, N, Grooten, J.
    Heterodimeric fusion proteins.
    Priority date 2000.06.30.
    WO02/02781 (10.01.2002) - US 2004/0220388 (04.11.2004)
    WO:
    US : 

  89. Contreras, R, Callewaert, N, Geysens, S.
    Protein glycosylation modification in Pichia Pastoris (methylotrophic yeast).
     Priority date 2000.06.30.
    WO02/00856 (03.01.2002) - US Patent 8,354,268 (15.01.2013) - US Patent 6,803,225 (12.10.2004)  - Eur. Patent EP1294910 (19.11.2008) - Austr. Patent AU2001277658 (19.10.2006)
    WO:
    US : & &

    EP :
    AU :

  90. Grooten, J, Sehra, S.
    Method to induce the Th1 immune response.
    Priority date 2000.06.07.
    WO01/94419 (13.12.2001) -  US 2003/0103966 (05.06.2003)
    WO:
    US : 

  91. Callewaert, N, Contreras, R, Molemans, F.
    Method for the analysis of picomole amounts of carbohydrates.
    Priority date 2000.05.26.
    WO01/92890 (06.12.2001)
    WO:  

  92. Van Roy, F, Bonné, S, Vanlandschoot, A.
    Novel plakoglobin interacting proteins.
    Priority date 2000.05.09.
    WO01/85933 (15.11.2001)
    WO:  

  93. Callewaert, N, Contreras, R, Laroy, W, Martinet, W.
    Conditional gene silencing in eukaryotes by promoter insertion.
    Priority date 1999.12.27.
    WO01/48229 (05.07.2001)
    WO:  

  94. Van Roy, F, Vanlandschoot, A, Janssens, B.
    Novel cDNAs encoding catenin-binding proteins with function in signalling and/or gene regulation.
    Priority date 1999.12.23.
    WO01/47954 (05.07.2001) - US Patent 6,767,720 (27.07.2004)  
    WO:  
    US : 

  95. De Bosscher, K, Vanden Berghe, W, Haegeman, G.
    Use of carboxy compounds such as 2(4-acetophenyl)-2-chloro-N-methyl-ethylammoniumchloride as anti-inflammatory agents.
    Priority date 1999.12.21.
    WO01/45693 (28.06.2001)  - US Patent 7,053,120 (30.05.2006) - EU Patent 1239850 (18.10.2006)
    WO:
    US : 
    EU :   

  96. Declercq, W, Vandenabeele, P, Lippens, S.
    Use of caspase-14 and caspase-14 modulators to diagnose and/or treat skin, eye and brain disorders.
    Priority date 1999.11.10.
    WO01/34183 (17.05.2001)
    WO:  

  97. Hans, W, Steidler, L, Remaut, E.
    Delivery of trefoil peptides.
    Priority date 1999.07.05.
    WO01/02570 (11.01.2001) - US Patent US7220418 (22.05.2007) - Eur. Patent EP1194554 (18.10.2006) & EP1739178 (08.09.2010) - Austr. Patent 781679 (09.06.2005)
    WO:
    US : 
    EP: &
    AU:

  98. Contreras, R, De Backer, M, Luyten, W, Malcorps, I, Nelissen, B, Reekmans, R.
    Cell death related drug targets in yeast and fungi.
    Priority date 1999.07.01.
    WO01/02550 (11.01.2001)  - US2005/0148062 (07.07.2005)
    WO:
    US : 

  99. Van Roy, F, Bonné, S.
    Means and methods for altering the functional properties in eukaryotic cells.
    Priority date 1999.04.30.
    WO00/66619 (09.11.2000)
    WO:  

  100. Cornelis, S, Beyaert, R.
    Internal ribosome entry site (IRES), vector containing same and uses thereof.
    Priority date 1999.01.26.
    WO00/44896 (03.08.2000) - US Patent 6,764,852 (20.07.2004) - Austr. Patent AU775750 (25.11.2004) 
    WO:  
    US: 
    AU: 

  101. Contreras, R, Nelissen, B, De Backer, M, Luyten, W, Viaene, J, Logghe, M.
    Drug targets in Candida albicans (2).
    Priority date 1998.08.14.
    WO00/34481 (15.06.2000) - US Patent 7,125,970 (24.10.2006) - Eur Patent 1135503 (21.02.2007)
    WO:
    US : 
    EU : 

  102. Steidler, L, Remaut, E, Fiers, W.
    Use of a cytokine-producing Lactococcus strain to treat colitis.
    Priority date 1998.10.20.
    WO00/23471 (27.04.2000) - US Patent 6,746,671 (08.06.2004) - Eur.Patent 1123314 (18.02.2004) - Austr. Patent AU770726 (26.02.2004)
    WO:  
    US: 
    EU: 
    AU: 

  103. Contreras, R, Nelissen, B, De Backer, M, Luyten, W, Viaene, J, Logghe, M.
    Drug targets in Candida albicans (1).
    Priority date 1998.08.14.
    WO00/09695 (24.02.2000)
    WO:  

  104. Van de Craen, M, Declercq, W, Vandenabeele, P, Fiers, W.
    New caspase homologue.
    Priority date 1998.07.17.
    WO00/04169 (27.01.2000) - US Patent 6,759,227 (06.07.2004) - Austr. Patent 763721 (31.07.2003)
    WO:  
    US: 
    AU:   

  105. Beyaert, R, Heyninck, K, Fiers, W.
    Novel inhibitors of NF-kB activation.
    Priority date 1998.05.06.
    WO99/57133 (11.11.1999) - US Patents 6,673,897 (06.01.2004) & 7,414,026 (19.08.2008)- Eur. Patent 1123314 (18.02.2004) - Austr. Patent 754434 (02.08.2001)
    WO:  
    US:  &
    EU: 

  106. Schoonjans, R, Mertens, N.
    Multipurpose antibody derivatives.
    Priority date 1998.01.23.
    WO99/37791 (29.07.1999) - US Patent 6,809,185 (26.10.2004) - Eur. Patent 1049787 (24.11.2004)
    WO:  
    US: 
    EU:   

  107. Desmedt, M, Fiers, W, Grooten, J.
    Inducible cellular immunity through activation of Th1 and suppression of Th2 responses by macrophages.
    Priority date 1997.10.23.
    WO99/21968 (06.05.1999) - Eur. Patent EP1032651 (16.08.2006) -  
    WO:
    EU :

  108. Neirynck, S, Min Jou, W, Fiers, W.
    New immunoprotective influenza antigen and its use in vaccination.
    Priority date 1997.08.05.
    WO99/07839 (18.02.1999) - US Patents 7,993,652 (09.08.2011) & 7,731,972 & 7,732,130 (08.06/2010) - Eur. Patent 0996717 (07.12.2005) - Austr. Patent AU745951 (11.04.2002)
    WO:  

    US : & &

    EU :

    AU :

  109. Mertens, N, Remaut, E, Fiers, W.
    Regulatory systems for inducible expression of genes with lambdoid promoters.
    Priority date 1997.04.23.
    WO98/48025 (29.10.1998) - US Patent 6,485,934 (26.11.2002) - Eur. Patent 0975775 (17.03.2004) - Austr. Patent AU729712 (08.02.2001)
    WO:  
    US:   
    EU:     
    AU: 

  110. Grooten, J, Dooms, H, Fiers, W.
    Use of interleukin-15.
    Priority date 1997.02.21.
    WO98/36768 (27.08.98) - US Patent 6,344,192 (05.02.2002) - Eur. Patent 0971728 (11.12.2002) -  
    WO: 
    US:  
    EU:

  111. Steidler, L, Remaut, E, Wells, J, Le Page, R.
    Delivery of biologically active polypeptides.
    Priority date 1995.10.20.
    WO97/14806 (24.04.1997) - US Patent 6,605,286 (12.08.2003) - Austr. Patent AU774535 (01.07.2004)
    WO:  
    US : 
    AU : 

  112. Steidler, L, Remaut, E, Wells, J.
    Materials and methods relating to the attachment and display of substances on cell surfaces.
    Priority date 1995.09.07.
    WO97/09437 (13.03.1997) - US Patent 6,190,662 (20.02.2001) - Eur. Patent 0848756 (30.06.2004) - Austr. Patent AU729449 (01.02.2001)
    WO :
    US : 
    EU : 

    AU : 

  113. Maras, M, Contreras, R.
    Methods of modifying carbohydrate moieties.
    Priority date 1994.12.30.
    WO96/21038 (11.07.1996) - US Patent 5,834,251 (10.11.1998) - Eur.  Patent 0799318 (22.03.2006)
    WO :  
    US :    
    EU : 

  114. Fiers, W, Deroo, T, Min Jou, W. 
    Influenza vaccine.
    Priority date 1994.01.11.
    WO95/18861 (13.07.1995) - US Patents 5,962,298 (05.10.1999) & 6,605,457 (12.08.2003) & 7,468,259 (23.12.2008) - Eur. Patent EP0733113 (02.05.2007) - Russian Patent 2186111 (2002) - Can. Patent 2180965 (11.05.2010)
    WO :
    US :  & &
    EU :
    Russia :
    Canada :

  115. Ameloot, P, Fiers, W, Van Haute, E, De Lafonteyne, J.
    Genetic manipulations with recombinant DNA comprising sequences derived from RNA virus.
    Priority date 1990.10.02.
    US Patent 6,197,542 (06.03.2001) - Can. Patent 2 396 794 (04.04.1991)
    CA :  
    US :    

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